Spravato (esketamine) is a magical and mysterious medication, highly effective for treating stubborn depression. These patient administered nasal devices have not only saved countless of my patients’ lives from suicide, but Spravato has rescued so many of them from being trapped in their negative perspectives. That being said, this medication is a powerful force and requires careful and thoughtful compassion and intentionality poured into each individual who opens themselves up to the healing properties this medication can provide.

Ketamine, originally known as a powerful anesthetic, has gained attention for its rapid antidepressant effects by acting on the NMDA receptor and modulating glutamate in the brain. In controlled clinical settings, ketamine has proven efficacy in treating severe and treatment-resistant depression. However, the growing trend of using ketamine at home, often without medical supervision, raises significant concerns.

In most cases, patients respond to esketamine and continue with regular dosing usually every 2-3 weeks. Infrequently, they will require redosing weekly or monthly. Stopping the medication after a response is uncommon and usual among those who have consistently mild depression.

If you have treatment resistant major depression, live in the Charleston SC or Mount Pleasant, SC area and are interested in scheduling a Spravato consultation, please call Sweetgrass Psychiatry at (843) 800-1303.