Spravato (esketamine) is a magical and mysterious medication, highly effective for treating stubborn depression. These patient administered nasal devices have not only saved countless of my patients’ lives from suicide, but Spravato has rescued so many of them from being trapped in their negative perspectives. That being said, this medication is a powerful force and requires careful and thoughtful compassion and intentionality poured into each individual who opens themselves up to the healing properties this medication can provide.

Ketamine, originally known as a powerful anesthetic, has gained attention for its rapid antidepressant effects by acting on the NMDA receptor and modulating glutamate in the brain. In controlled clinical settings, ketamine has proven efficacy in treating severe and treatment-resistant depression. However, the growing trend of using ketamine at home, often without medical supervision, raises significant concerns.

If you have treatment resistant major depression, live in the Charleston SC or Mount Pleasant, SC area and are interested in scheduling a Spravato consultation, please call Sweetgrass Psychiatry at (843) 800-1303.

Depression that does not respond to 2 or more antidepressant medications of therapeutic dose for at least 6 weeks is what I call “sticky depression” or more formally, treatment resistant depression. Luckily it does not have to be treatment resistant anymore because I have 2 major weapons against “sticky depression” - Transcranial Magnetic Stimulation (TMS) and Spravato (esketamine nasal spray). Luckily, both are very safe, FDA approved/cleared, and are covered by most major insurance plans. Often, the biggest challenge is deciding which treatment is best for my individual patient because most patients are great candidates for both treatments.

When other traditional treatments for depression are not working, such as psychotherapy, medications (SSRIs, SNRIs), exercise, and healthy eating, there are other great treatment options. At Sweetgrass Psychiatry in Mount Pleasant, SC, we are pleased to provide our patients with treatment resistant depression HOPE. One evidence based, safe treatment option is Intramuscular (IM) ketamine.