Spravato (esketamine) is a magical and mysterious medication, highly effective for treating stubborn depression. These patient administered nasal devices have not only saved countless of my patients’ lives from suicide, but Spravato has rescued so many of them from being trapped in their negative perspectives. That being said, this medication is a powerful force and requires careful and thoughtful compassion and intentionality poured into each individual who opens themselves up to the healing properties this medication can provide.

In most cases, patients respond to esketamine and continue with regular dosing usually every 2-3 weeks. Infrequently, they will require redosing weekly or monthly. Stopping the medication after a response is uncommon and usual among those who have consistently mild depression.

If you have treatment resistant major depression, live in the Charleston SC or Mount Pleasant, SC area and are interested in scheduling a Spravato consultation, please call Sweetgrass Psychiatry at (843) 800-1303.

Depression that does not respond to 2 or more antidepressant medications of therapeutic dose for at least 6 weeks is what I call “sticky depression” or more formally, treatment resistant depression. Luckily it does not have to be treatment resistant anymore because I have 2 major weapons against “sticky depression” - Transcranial Magnetic Stimulation (TMS) and Spravato (esketamine nasal spray). Luckily, both are very safe, FDA approved/cleared, and are covered by most major insurance plans. Often, the biggest challenge is deciding which treatment is best for my individual patient because most patients are great candidates for both treatments.