Often there is a need or want for a patient to stop an antidepressant. For some antidepressants, like fluoxetine, this is easy. For other antidepressants, such as venlafaxine, this is notoriously difficult and uncomfortable with symptoms such as malaise, fatigue, nausea, achiness, and more. When discontinuing antidepressants, many people search for ways to minimize potential withdrawal symptoms, referred to as “discontinuation syndrome.” Two supplements recently began appearing on social media claiming to minimize these symptoms: high-dose omega-3 fatty acids and magnesium. Both have been studied for their potential benefits in treating depressive symptoms, but is there any evidence to support their use specifically for minimizing discontinuation syndrome?